Dezocine PCEA Effectivey controls Pain and Improves Patient Outcomes in Total Myomectomy, study finds

China: A recent study has shown the effectiveness of dezocine in patient-controlled epidural analgesia (PCEA) in controlling pain associated with total myomectomy, has less impact on patients' sleep, and reduces the negative impact of stress factors, leading to fewer adverse effects. The findings were published online in the World Journal of Clinical Cases.
Uterine fibroids are frequently occurring benign gynecological conditions. Treatment typically involves medication for patients experiencing excessive menstruation, anemia, and pressure symptoms. In severe cases, a total hysterectomy may be necessary, although this procedure is invasive and can lead to significant postoperative pain. This discomfort may impact the patient's sleep quality after surgery, affecting the overall recovery process.
Patient-controlled epidural analgesia is a widely used method for self-administered pain relief, typically employing low concentrations of opioid analgesics. Morphine is currently the predominant choice due to its effective pain management capabilities. However, it can induce side effects such as nausea and vomiting, especially in patients undergoing total hysterectomy, possibly due to hormonal and endocrine factors. Dezocine, a phenylmorphanolane derivative, exhibits analgesic effects that correlate closely with dosage. Comparative studies evaluating equivalent analgesic doses of sufentanil, fentanyl, and dezocine have demonstrated that dezocine offers a better safety profile with less impact on consciousness levels and fewer adverse reactions.
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