Dezocine PCEA Effectivey controls Pain and Improves Patient Outcomes in Total Myomectomy, study finds

Against the above background, Feng-Feng Ning, Department of Anesthesiology, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu Province, China, and colleagues aimed to evaluate dezocine in patient-controlled epidural analgesia use for postoperative pain management in patients undergoing total myomectomy.

For this purpose, they selected 100 patients undergoing total abdominal hysterectomy for uterine fibroids. They randomized them into two groups; a control group received 0.2% ropivacaine plus 0.06 mg/mL of morphine, and an observation group received 0.2% ropivacaine plus 0.3 mg/mL of diazoxide in their PCEA. Outcomes evaluated included pain levels, recovery indices, sedation, stress factors, PCEA usage, and sleep quality.

The following were the key findings of the study:

• The observation group showed lower visual analog scale scores, shorter postoperative recovery indices, fewer mean PCEA compressions, lower cortisol, and blood glucose levels, and better polysomnographic parameters than the control group.
• The cumulative incidence of adverse reactions was lower in the observation group than in the control group.

The researchers conclude, "We explored the effectiveness of dezocine PCEA in pain management following total hysterectomy. Initial findings suggest that dezocine PCEA effectively alleviates post-procedural pain, mitigates the impact of stress factors, enhances sleep quality among patients, and reduces the incidence of adverse reactions. These outcomes offer significant implications for clinical anesthesia practices."

Reference:

Ning, Feng-Feng, et al. "Application of Dezocine Patient-controlled Epidural Analgesia in Postoperative Analgesia in Patients With Total Myomectomy." World Journal of Clinical Cases, vol. 12, no. 20, 2024, pp. 4265-4271.