Elevated serum androgen levels in patients with PCOS associated with multiple metabolic abnormalities: Study

Results: The body mass index, waist-to-hip ratio, mF-G score, and acne score, as well as T, LH, LSH/FSH, FPG, Cr, UA, TG, TC, and LDL-C levels were significantly higher in the PCOS group than in the control group. The incidence of hyperandrogenism and clinical hyperandrogenism in the PCOS group was significantly higher than that in the control group. Regarding clinical hyperandrogenism, hirsutism, acne, and acanthosis nigricans were significantly more common in the PCOS group than in the control group. Serum androgen levels were significantly correlated with the mF-G score, acne score, FSH, glucose concentration at 30 min, glucose concentration at 60 min, glucose concentration at 120 min, FINS, N120, HOMA-IR, HbA1c, AUCG, UA, TG, and hHDL-Clevels. Elevated serum androgen levels are commonly observed in patients with PCOS and are associated with multiple metabolic abnormalities. Therefore, it is recommended to regularly monitor glucose and lipid metabolism-related indicators in patients with PCOS who have elevated androgen levels.

Reference:

Ting Z, Xinghua T, Xiao X, Lingchuan L, Xiaomei W, Tao Y. The impact of androgen levels on serum metabolic profiles in patients with polycystic ovary syndrome. Gynecol Endocrinol. 2024 Dec;40(1):2352136. doi: 10.1080/09513590.2024.2352136. Epub 2024 May 11. PMID: 38733359.