Esketamine may provide pain relief during C-section without neonatal depression: JAMA
China: A new trial published in JAMA Network Open has found that a subanesthetic dose of esketamine, administered before cesarean delivery, can provide temporary pain relief and sedation without significant neonatal depression.
Although epidural anesthetic is the preferred method for cesarean delivery, additional analgesics are frequently required to ease pain during uterine traction. The purpose of this trial was to look at the sedative and analgesic effects of intravenous esketamine given before childbirth through cesarean delivery while the patient was under epidural anesthesia.
The study was multicenter, double-blind, randomized clinical trial, that involved 903 women, 18 years and older, who were scheduled for elective cesarean delivery with epidural anesthesia in five medical centers in China.
The patients were given an intravenous injection of 0.25 mg/kg of esketamine or placebo before incision. The study's primary outcomes included scores on the numeric rating scale of pain and the Ramsay Sedation Scale immediately after fetal delivery. The secondary outcome was neonatal Apgar score assessed at 1 and 5 minutes after birth.
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