Esketamine pretreatment may reduce incident postpartum depression after cesarean section
In a recent study, researchers have discovered that the intraoperative use of esketamine, an enantiomer of ketamine, may significantly reduce the incidence of postpartum depression (PPD) in women undergoing cesarean section. This study was published in the journal BMC Anesthesiology by Shixia Xu and colleagues. The study, which involved 319 parturients, compared the effects of esketamine with a control group receiving a saline solution.
The randomized trial administered 0.2 mg/kg of esketamine to the study group during the cesarean section, while the control group received an equivalent volume of saline. The drugs were pumped for 40 minutes starting from the beginning of the surgery.
Results from the study demonstrated a noteworthy decrease in the incidence of PPD, as measured by Edinburgh Postnatal Depression Scale (EPDS) scores, at 4 days post-surgery in the esketamine group compared to the control group (13.8% vs. 23.1%, P = 0.0430). However, this positive effect was not sustained at 42 days after surgery (P = 0.0987).
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