Estradiol tablets lower pH and improve genitourinary health in postmenopausal women: JAMA study

USA: The use of vaginal estradiol tablets for treating genitourinary symptoms of menopause changes the vaginal microenvironment in ways that may promote genitourinary health, according to results from a secondary analysis of a randomized clinical trial. The study was published in JAMA Network Open on  March 30, 2022. 

"Vaginal estradiol tablets resulted in substantial changes in the vaginal microbiota and metabolome with a pH lowering, this was seen particularly in women with high-diversity bacterial communities at baseline," Sujatha Srinivasan, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, and colleagues wrote in their study.

"Placebo or low pH moisturizer despite lowering the vaginal pH, did not significantly impact the vaginal microbiota or metabolome implying that estradiol use may offer additional genitourinary health benefits to postmenopausal women."

Vaginal estradiol or moisturizer is often prescribed to postmenopausal women with genitourinary symptoms of menopause for symptom improvement. However, the impact of these treatments on the local microenvironment is not well understood. 

Against the above backdrop, Dr, Srinivasan and the team aimed to compare changes in the vaginal microbiota, metabolome, and pH among women using low-dose vaginal estradiol tablet or low pH moisturizer gel for 12-weeks vs low pH placebo. 

In this, post hoc prespecified secondary analysis of a 12-week multicenter randomized clinical trial among postmenopausal women with moderate to severe genitourinary symptoms, women were enrolled between April 2016 and February 2017. Final follow-up visits occurred in April 2017.  Women were randomized to receive ten-μg vaginal estradiol plus placebo gel vs placebo tablet plus vaginal moisturizer vs dual placebo. Changes in the diversity and composition of the vaginal microbiota, changes in the metabolome, and pH were the main outcomes. 

144 women (mean age, 61 years) were included in this analysis from 302 postmenopausal women from the parent trial. 

"A significant decrease in pH over the course of trial may not reflect the same underlying biological processes among different interventions, and thus, pH lowering should not be a primary goal," wrote the authors.

The metric of lowering vaginal pH in accordance with FDA guidelines for primary efficacy analyses in clinical trials in GSM is a blunt measure, they noted. 

To conclude, treatment of genitourinary symptoms of menopause with topical estradiol changes the vaginal microenvironment in ways that may promote genitourinary health.

Reference:

Srinivasan S, Hua X, Wu MC, et al. Impact of Topical Interventions on the Vaginal Microbiota and Metabolome in Postmenopausal Women: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2022;5(3):e225032. doi:10.1001/jamanetworkopen.2022.5032