Exposure to certain industrial chemicals tied to early menopause

The Investigators conducted a prospective cohort study to investigate associations between perfluoroalkyl substances and incident natural menopause.

They found that Per- and polyfluoroalkyl substance (PFAS) exposure may cause menopause to occur two years earlier in women The  new study has been published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

Known as 'forever chemicals,' PFAS are humanmade and used in a wide variety of nonstick and waterproof products and firefighting foams. PFAS chemicals can contaminate drinking water, and it has been estimated that 110 million Americans (one out of three) may consume drinking water contaminated with these chemicals.

"PFAS are everywhere. Once they enter the body, they don't break down and build up over time," said the study's lead author Ning Ding, Ph.D., M.P.H., of the University of Michigan School of Public Health in Ann Arbor, Mich. "Because of their persistence in humans and potentially detrimental effects on ovarian function, it is important to raise awareness of this issue and reduce exposure to these chemicals."

The researchers studied 1,120 midlife women from the Study of Women's Health Across the Nation, a 17-year-long prospective cohort study. They found that women with high PFAS levels in their blood samples reached menopause two years earlier than those with lower levels.

"Even menopause a few years earlier than usual could have a significant impact on cardiovascular and bone health, quality of life, and overall health in general among women," said corresponding author Sung Kyun Park, Sc.D., M.P.H., of the University of Michigan School of Public Health.

DOI: 10.1210/clinem/dgaa303