HCQS reduces Preeclampsia in SLE-affected pregnancy, while aspirin has no role, study confirms
Australia: A single-centre retrospective study of lupus-affected pregnancies has concluded that hydroxychloroquine significantly lowers the risk of preeclampsia.
The researchers have also added that there is no association between aspirin and preeclampsia.
The findings of the study are published in the Pregnancy Hypertension.
It is already known that Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease affecting women of childbearing age disproportionately. Preeclampsia occurs in approximately 25 % of SLE-affected pregnancies, which further increases the complications (both maternal and fetal).
Hydroxychloroquine (HCQ) has properties (anti-inflammatory, antioxidant, anti-thrombotic) which impacts the outcomes of pregnancy in such cases. It is recommended in pregnant women with SLE because it reduces the disease flare risk. But its role remains uncertain, and it has conflicting results.
Studies suggest aspirin significantly reduces preterm preeclampsia (high-risk women) and is therefore recommended for prophylaxis due to the pro-angiogenic effect. This effect is theoretical and has no evidence that it significantly reduces risk in this population group.
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