Higher Aspirin Dose May Reduce Preeclampsia Risk in High-Risk Obese Pregnant Women, unravels study
A recent randomized trial published in the American Journal of Obstetrics and Gynecology unveiled that a higher dose of aspirin may reduce the risk of preeclampsia (PE) with severe features in high-risk obese pregnant women. Preeclampsia is characterized by high blood pressure and signs of damage to other organ systems, often affects the pregnant women. This in turn can lead to serious complications for both mother and baby. Preventive measures, including the use of low-dose aspirin, have been recommended to reduce these risks. However, recent data have raised concerns about the adequacy of the 81 mg dose, particularly in obese women, who may experience aspirin resistance by potentially diminishing the efficacy of drugs.
The study compared the efficacy of 162 mg of aspirin daily to the standard 81 mg dose, which is currently recommended by leading medical societies in the US for women at risk of PE. The study included a total of 220 participants between May 2019 and November 2022 with a body mass index (BMI) of 30 kg/m² or higher and at least one additional high-risk factor like a history of PE in a prior pregnancy, stage I hypertension, or diabetes diagnosed before 20 weeks of gestation.
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