Study demonstrates causal relationship between lymphocyte and T cell count with pre-eclampsia and eclampsia.
Pre-eclampsia and eclampsia are two of the most serious acute multisystemic disorders during pregnancy and are significant determinants of maternal and neonatal mortality on a global scale. Pre-eclampsia is associated with an elevated susceptibility to adverse pregnancy outcomes, such as preterm birth and intrauterine growth restriction, thereby amplifying the risk of low birth weight. Furthermore, it is intricately linked to serious maternal and neonatal health complications, including chronic hypertension, maternal end-stage renal disease, and neonatal pulmonary dysplasia. The precise etiology of pre-eclampsia remains elusive, although our current understanding suggests that women afflicted with pre-eclampsia exhibit increased uterine artery resistance due to impaired immune regulation. This, in turn, contributes to the activation of the maternal endothelium and the onset of systemic chronic inflammation. Multiple studies have found that immune cells change significantly in women with pre-eclampsia.
Mendelian randomization (MR) presents a robust means to investigate the causal relationship between immune cells and pre-eclampsia by genetic variants (single nucleotide polymorphisms (SNPs)), and it is also less susceptible to the shortcomings of classical epidemiological studies, such as confounding bias, information bias, and selection bias. Recently, the application of MR has gained significant traction in elucidating the causal link between immune cells and various diseases such as hypertension, amyotrophic lateral sclerosis and multiple sclerosis. In this study, authors utilized MR and colocalization analysis to investigate the potential causal association between immune cells and pre-eclampsia.
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