How does glucocorticoid therapy affect development of cardiovascular system during pregnancy?

Glucocorticoid therapy is widely used during pregnancies at risk of premature delivery to promote fetal lung maturation. While it is an effective treatment, it can also trigger heart and blood vessel problems. New research published in The FASEB Journal uncovers the mechanisms behind the cardiovascular-related effects of the most commonly used glucocorticoids, Dexamethasone (Dex) and Betamethasone (Beta).

When investigators treated chicken embryos with these different glucocorticoids, they found that both caused growth restriction, with Beta being more severe. At the level of the heart, both treatments promoted cellular stress and changes to the cell cycle, but via different molecular pathways. Whereas Dex induced oxidative stress and lowered the activation of the glucocorticoid receptor, Beta treatment led to sustained glucocorticoid receptor activation, and it did not induce oxidative stress. Beta compared with Dex induced greater cardiac dysfunction. Also, Dex triggered an increase in heart muscle cell numbers, but Beta promoted a decrease. In blood vessels, Beta impaired blood vessel dilation, whereas Dex resulted in greater blood vessel constriction.