HPV vaccination not tied to infertility in younger females

The researchers used 2013 to 2016 National Health and Nutrition Examination Surveys, and analyzed the data of 1,114 women 20 to 33 years old.

Two logistic regression models were created and stratified by marital history. The first model evaluated the likelihood of infertility in women who had never been pregnant or were pregnant before vaccination. The second model included all women 20 to 33 years old who reported that they were infertile for any 12-month period, to account for potential delayed and/or nondurable post-vaccine infertility.

It was found in that in all 8.1% reported infertility. The women in the first model who were or had been married and had been vaccinated against HPV were less likely than others to report infertility (odds ratio, 0.04; 95% confidence interval, 0.01 to 0.57). No other association between HPV vaccination and infertility was identified.

"These results provide further evidence of HPV vaccine safety and should give providers confidence in recommending HPV vaccination," the authors wrote. "Further research should explore protective effects of HPV vaccines on female and male fertility."

These findings should lessen concern about potential impact on fertility from adolescent vaccination.

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Apr 3 Vaccine study