Hypertensive disorders of pregnancy in Black women raise long-term risk of stroke: NEJM

USA: A recent study published in the New England Journal of Medicine Evidence has revealed that black women with a history of hypertensive disorders of pregnancy (HDOP) have an estimated 66% increased long-term risk of stroke.

A newly published study focuses on data gathered over 25 years from 59,000 Black women in the Black Women’s Health Study (BWHS) and is led by researchers from Boston University Chobanian & Avedisian School of Medicine and Slone Epidemiology Center.

“Our results may explain, in part, the disproportionately high incidence of stroke in Black women relative to other populations,” said corresponding author Shanshan Sheehy, MD, ScD, assistant professor of medicine at the school and an investigator at the Slone Epidemiology Center.

Black women have a disproportionately higher burden of preeclamptic pregnancy and stroke than white women. Still, virtually all existing evidence on the association between the two medical conditions has come from studies of white women.

In the presence study, the researchers looked at U.S. Black women enrolled in the BWHS, including 42,924 participants who had given birth and were free of cardiovascular disease before entry into the analysis. Biennial questionnaires asked about preeclampsia, gestational hypertension, and stroke, among other conditions. Medical records were sought for self-reports of stroke and were reviewed by neurologists.

Over the period from 1995 through 2019, there were 1,555 strokes, including 310 among 4,938 women with a history of HDOP. Women who reported a history of HDOP were estimated to have 1.66 times the risk of stroke relative to parous women who had not had those pregnancy complications; for history of preeclampsia in particular, the estimated HR was 1.53. The association was present among younger and older women (age less than 60). It was also present among women who were not overweight in young adulthood as well as women who were overweight or obese at that time.

Preeclampsia affects approximately 2 to 8% of pregnancies and is the second leading cause of maternal mortality worldwide. Preeclampsia/eclampsia among Black women in the U.S. is 60% higher than among white women (70 per 1,000 deliveries in 2014 for Black women vs. 43 per 1,000 for white women). In recent years, rates of severe preeclampsia have been increasing for Black women.

The American Heart Association (AHA) guidelines recently added pregnancy complications to their list of risk factors for stroke. However, the recommendations were based largely on data from women of Northern European ancestry. The AHA has called for more research on the risk of stroke in women, especially women from underrepresented populations.

“Our study provides evidence that pregnancy history may be an important factor for risk assessment and prevention of long-term stroke,” said Sheehy. “Cardiovascular screening recommendations for Black women, in particular, should take the history of HODP into account.”

Reference:

Shanshan Sheehy, Hugo J. Aparicio, Nuo Xu, Kimberly A. Bertrand, Yvonne Page Robles, Vasileios-Arsenios Lioutas, Julie G. Shulman, Lynn Rosenberg, DOI: 10.1056/EVIDoa2300058.