Is there a relation between stillbirth Risk in Grandchild and Grandmother's Obesity?
Written By : Aditi
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2023-12-19 22:30 GMT | Update On 2023-12-19 22:30 GMT
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Women's obesity and overweight problems have reached epidemic levels, making them the most significant preventable risk factors for stillbirth.
Eduardo Villamor, in a recent investigation published in the American Journal of Epidemiology, said grandmaternal overweight and obesity are associated with grand offspring stillbirth.
In this Swedish population-based study, researchers investigated the association between maternal grandmaternal early pregnancy BMI and grand offspring stillbirth risk. This three-generation cohort included nearly 176,908 grandmothers, 197,579 mothers, and more than 316,459 grand offspring born 1997-2016, using Swedish Medical Birth Register.
Key findings are:
- There were 998 stillbirths reported in grand offspring with risk, 3.2 per 1000 births.
- Compared to the grandmaternal normal BMI of 18.5-24.9 mg/kg2, stillbirth risk increased by 41 % (Relative risk 1.41).
- With increasing BMI ≥30, stillbirth risk increased by 62 % (relative risk 1.62).
- Maternal overweight and obesity in early pregnancy increased stillbirth risk in offspring by 32% and 77%, respectively.
- As indicated by causal mediation analysis, Maternal BMI mediated only 19% of this relation.
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