Letrozole with FSH had similar pregnancy rates in obese and nonobese PCOS women, claims research
Obesity is considered as one of the most frequently observed risk factors for infertility in both males and females as well, as it interferes with the success of the treatment of fertility.
Higher body mass index is associated with infertility, especially ovulatory disorders. Obese women under treatment for infertility may face additional problems, such as the need for higher doses of drugs to induce/stimulate ovulation, oocyte morphological changes, reduction in fertilization and implantation rates, and embryo quality.
Letrozole and clomiphene citrate are commonly used drugs for ovulation induction with or without gonadotropins in anovulatory women especially polycystic ovarian syndrome. Letrozole, a short half-life aromatase inhibitor(45 hours), has shown more successful ovulation induction in polycystic ovarian syndrome (PCOS) patients.
In cases of poor follicular response, low doses of FSH are given as a cotherapy with letrozole to enhance follicular development and maturity. Letrozole cotreatment with gonadotropins was found to cause a higher incidence of monofollicular growth which is an advantage that reduces the risks of hyperstimulation effect of ovulation induction therapy. Letrozole was also used in unexplained infertility and found to be as effective as clomiphene citrate with reduced multiple births. However, a combination of letrozole and gonadotropins has not been studied extensively either in PCOS patients or unexplained infertility, in relation to obesity. Therefore, the goal of this study was to assess the success of ovulation induction with letrozole combined with FSH in obese and nonobese women. The main intention was to study the impact of obesity on fertility outcome, when FSH was used along with letrozole.
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