Live birth rates increases with increasing endometrial thickness in fresh embryo transfer: Study
Endometrial thickness is measured routinely in in vitro fertilization (IVF) cycles. Neal Mahutte and team’s recent study’s main objective was to determine in fresh IVF-ET and FET cycles if there is an endometrial thickness at which live birth rates peak and if there is an endometrial thickness beyond which live birth rates decline. They also sought to investigate if patient age, the timing of embryo transfer (cleavage stage vs. blastocyst), or the number of retrieved oocytes affect the relationship between endometrial thickness and live birth rates. Finally, they evaluated the relationship between endometrial thickness and term singleton birthweight. In cycles with a fresh embryo transfer, live birth rates increase with increasing endometrial thickness until 10–12 mm, and in FET cycles live birth rates plateau after 7–10 mm. There does not appear to be a thickness above which pregnancy outcomes worsen.
In this retrospective cohort study, authors analyzed all autologous cycles from the CARTR Plus database that resulted in an embryo transfer from 2013 to 2019. During this period, data were available from 33 Canadian ART clinics. The endometrial thickness in fresh IVF-ET cycles was recorded on the day of trigger, while for FETs it was recorded before the initiation of progesterone or documentation of luteinizing hormone surge or HCG administration. Cleavage stage and blastocyst transfers were included, and blastocyst transfers on days 5 and 6 were analyzed together.
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