Lower Citrate Levels Linked to Increased Risk of Gestational Diabetes, suggests study
Researchers have found a negative correlation between citrate levels in pregnant women and the occurrence of gestational diabetes mellitus, suggesting that lower citrate levels may be associated with a higher risk of developing the condition.
Diabetes Mellitus (GDM) is a common metabolic disease during pregnancy, mainly manifested as impaired glucose tolerance in the middle and late stages of pregnancy. As a key intermediate product in the tricarboxylic acid cycle, citrate has been widely recognized for its role in regulating blood glucose levels. However, the potential association between citrate and impaired glucose tolerance during pregnancy needs further research, The aim of this study is to investigate the relationship between citrate levels in the human body and the incidence of gestational diabetes mellitus.
This study adopts a two-sample Mendelian randomization approach, using genetic variants of citrate as instrumental variables, to investigate the causal relationship between citrate and gestational diabetes mellitus (GDM). The research data is derived from the OpenGWAS and FinnGen databases, with single nucleotide polymorphisms (SNPs) related to citrate levels and the incidence of GDM selected as analytical tools. Citrate is designated as the exposure factor, and GDM as the outcome variable. Comprehensive assessments of the causal relationship between the instrumental variables and GDM are conducted using methods such as Inverse Variance Weighted (IVW), MR Egger, Simple Mode, Weighted Median, and Weighted Mode. Additionally, Cochran’s Q and I^2 statistics are utilized to evaluate heterogeneity, with visualization provided through funnel plots. To test the robustness of the results, a leave-one-out sensitivity analysis method is employed.
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