Microplastics Detected in Human Ovarian Fluid for the First Time: A Rising Concern for Female Fertility, Study Shows

The researchers propose that MPs might reach the ovaries through the bloodstream and accumulate in granulosa cells within the follicular fluid. While the immediate effects on fertility outcomes appear minimal, the presence of MPs in such a sensitive biological environment raises important questions about the potential for longer-term reproductive harm.

The researchers note that animal studies have previously demonstrated that microplastics can negatively impact ovarian function, prompting concerns that humans may face similar risks. The current findings serve as a wake-up call to the medical and scientific communities about the deeper biological penetration of these synthetic pollutants.

Although the sample size was small and no direct adverse reproductive outcomes were observed, the researchers emphasized the importance of continued investigation. This initial evidence underlines the need for broader studies to assess whether chronic exposure to microplastics might influence female fertility or hormonal balance over time.

"As environmental microplastic contamination continues to rise, this study provides critical groundwork for understanding how these pervasive particles may impact human health in previously unimagined ways," the researchers wrote, concluding that "further research will be essential to determine whether interventions or preventive strategies can help mitigate the potential reproductive risks associated with microplastic exposure."

Reference:

Montano, L., Raimondo, S., Piscopo, M., Ricciardi, M., Guglielmino, A., Chamayou, S., Gentile, R., Gentile, M., Rapisarda, P., Oliveri Conti, G., Ferrante, M., & Motta, O. (2025). First evidence of microplastics in human ovarian follicular fluid: An emerging threat to female fertility. Ecotoxicology and Environmental Safety, 291, 117868. https://doi.org/10.1016/j.ecoenv.2025.117868