New Ultrasound-Driven Model Boosts Accuracy in Diagnosing Endometrial Malignancy: Study Shows
China: A new study published on April 21 in the Journal of Radiation Research and Applied Sciences has shown that combining clinical parameters with ultrasound imaging significantly improves the detection of endometrial malignancy in postmenopausal women.
The research, led by Dr. Xiu Yun Dong and her team at the Jinan Maternal and Child Health Hospital Affiliated with Shandong First Medical University, emphasizes a more personalized approach to evaluating endometrial thickening. The study aims to evaluate the diagnostic effectiveness of transvaginal ultrasound (TVUS) and to develop a multivariable risk stratification model for identifying endometrial malignancy and precursor lesions in postmenopausal women presenting with asymptomatic endometrial thickening.
For this purpose, the researchers analyzed retrospective data from 587 postmenopausal women who had asymptomatic endometrial thickening detected during routine transvaginal ultrasound examinations. Participants were categorized based on histopathological results—221 women were found to have malignant or precursor lesions, while 366 had benign outcomes.
By developing a multivariable risk stratification model, the researchers aimed to better distinguish which women were more likely to have underlying malignancies. The model incorporated ultrasound findings—such as endometrial thickness, border irregularities, and heterogeneous texture—alongside clinical data like age, BMI, and diabetes status.
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