No Increased Risk of Major Congenital Malformations with First Trimester Tetracycline Use: JAMA
Sweden: A recent cohort study has explored the potential link between first-trimester exposure to tetracycline antibiotics and the risk of major congenital malformations (MCMs) in newborns. Tetracyclines, a class of antibiotics commonly used to treat bacterial infections, have been previously associated with a range of potential side effects, including concerns about fetal development when used during pregnancy.
The new research, published in JAMA Network Open revealed that although first-trimester tetracycline exposure was not linked to an increased risk of major congenital malformations, larger studies are needed to further investigate potential risks associated with specific malformation subgroups and individual defects.
Given the limited safety data on tetracycline antibiotic use during pregnancy, Aya Olivia Nakitanda, Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, and colleagues aimed to investigate the potential association between first-trimester exposure to tetracyclines and the risk of major congenital malformations.
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