Ondansetron or metoclopramide, which is better for managing hyperemesis gravidarum?
Jordan: Ondansetron and metoclopramide seem to be equally effective for managing hyperemesis gravidarum (HG) among parturient females, says a study published in the Turkish Journal Of Obstetrics And Gynecology. However, due to the trending therapeutic efficacy and better safety profile of ondansetron, it is favored over metoclopramide.
Hyperemesis gravidarum is a pregnancy complication characterized by pernicious vomiting that affects various areas of the woman's health including electrolytes, homeostasis, and kidney function, and may have adverse fetal consequences.
Ebraheem Albazee, Faculty of Medicine, The Hashemite University, Zarqa, Jordan, and colleagues aimed to investigate the efficacy of ondansetron (intervention) versus metoclopramide (control) for treating parturient females with hyperemesis gravidarum.
For this purpose, the researchers polled data from randomized controlled trials (RCTs) using a meta-analysis approach. Five information sources were screened from inception until January 2022. Cochrane Risk of Bias (version 2) assessment tool was used for quality assessment. A total of five RCTs comprising a total of 695 patients (355 and 340 females were assigned to ondansetron and metoclopramide, respectively) were included.
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