Optimizing TIRp and Mean Glucose Levels in second trimester Reduces Fetal Risks in T1D Pregnancies: Study

• LGA was higher among those with TIRp < 59.1% (50%) compared with those with TIRp > 59.1% (17.9%) (p = 0.010).

• Hyperbilirubinemia was also more common in the former where TIRp < 59.1% (45%) in comparison to TIRp better the latter groups (11.8%) (p = 0.016).

• The optimal TIRp cut-off point which identified as being able to reduce risk for LGA was > 59.1 % during the second trimester with a measure of sensitivity at 75% and specificity at 61% and an AUC of 0.68 (CI 0.48 – 0.88).

• It reflected a reduced risk for LGA with sensitivity at 69%, specificity 70%, and an AUC at 0.70 (CI 0.51-0.88).

• The third trimester was attained with improved metabolic control in women with AHCL devices compared to those on other devices of insulin delivery.

In conclusion, it is evident that keeping TIRp > 59.1% and mean glucose < 133 mg/dL during the second trimester confers reduced risks of LGA in the pregnancy outcomes of women with T1D. AHCL systems also support better metabolic control hence promising as a tool in the management of T1D pregnancies. Further research into the observed outcomes may validate the adoption of these metrics as the standard in handling these pregnancies.

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