PCOS linked to poor health and quality of life beyond reproductive years

WASHINGTON—Polycystic ovary syndrome (PCOS) is associated with decreased health-related quality of life (HRQoL), but longitudinal data beyond the reproductive years are lacking, and the impact of isolated PCOS symptoms is unclear.

According to new research, women with PCOS experience poor health and quality of life in their late forties. The new research has been published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

PCOS is a common yet underdiagnosed condition affecting 6–18 percent of women at reproductive age, but its side effects extend beyond infertility and menstrual irregularities. Women with PCOS experience psychological issues like anxiety and depression that continue well beyond fertile age.

"Most PCOS studies focus on women during reproductive age, but symptoms like mental health issues and excess hair growth continue into the late forties," said the study's principal investigator, Terhi Piltonen, M.D., PhD of the University of Oulu in Finland. "Our study focuses on this population and shows that women with PCOS have lower life satisfaction and poorer health up to their late reproductive years."

The researchers studied a longitudinal cohort of 5,889 women at ages 31 and 46 and identified women with PCOS from this Northern Finland Birth Cohort 1966. The investigators found women with PCOS have poor health and quality of life compared to those without the condition. Mental distress was the strongest contributing factor to poor quality of life.

"More interventions are needed to improve the quality of life for women with PCOS who are in their late thirties and forties. These women should be screened regularly for mental health issues and treated for other distressing symptoms like excess hair growth," Piltonen said.

Other authors include Salla Karjula, Laure Morin-Papunen, Juha Auvinen, Jouko Miettunen, Marjo-Riitta Järvelin, and Jari Jokelainen of the University of Oulu; Stephen Franks of the Imperial College London in the United Kingdom; and Juha S. Tapanainen of the University of Oulu and Helsinki University Hospital in Finland.

The study was supported by the Finnish Medical Foundation, the Academy of Finland, Sigrid Jusélius Foundation, the Finnidsh Cultural Foundation, the National Institute for Health Research, and the Medical Research Council.

The manuscript, "Population-based Data at Ages 31 and 46 Show Decreased HRQoL and Life Satisfaction in Women with PCOS Symptoms," was published online, ahead of print.

For more details click on the link: https://doi.org/10.1210/clinem/dgz256