Preconception use of GLP-1 Receptor Agonists tied to Lower Pregnancy Risks reveals research
Researchers have found in a new study that Use of GLP-1 receptor agonists before pregnancy was associated with reduced risks of hypertensive disorders, gestational diabetes, preterm birth, and cesarean delivery. Further women prescribed GLP-1 receptor agonists up to two years before conception were less likely to experience these complications. The findings were published in the American Journal of Obstetrics and Gynecology.
The use of glucagon-like-peptide-1 receptor agonists (GLP-1RAs) has greatly increased in patients of reproductive age within the past four years. However, there is minimal research into the long-term impact of these medications on future pregnancies. They aimed to evaluate the association between adverse obstetric outcomes and antecedent GLP-1RA use using a nationally representative database.
They conducted a retrospective cohort study of female patients age ≥ 18 using the United States Collaborative Network in TriNetX. We defined the exposure cohort as individuals who received a GLP-1RA prescription within 2 years preceding a pregnancy. The unexposed cohort comprised individuals with a history of pregnancy but no prior history of GLP-1RA use. Cohorts were matched for age, race, ethnicity, and history of co-morbid conditions. ICD-10 codes for hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), preterm delivery, and rates of Cesarean section (CD) were the primary outcomes of interest compared between the cohorts. Logistic regression was performed in TriNetX to determine odds ratios (OR) and 95% confidence intervals (CI).
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