Prophylactic calcium reduces postspinal hypotension during cesarean delivery in preeclamptic women receiving magnesium supplements: Study
Prophylactic calcium reduces postspinal hypotension during cesarean delivery in preeclamptic women receiving magnesium supplementation suggests a study published in the American Journal of Obstetrics & Gynecology MFM.
Preeclamptic women, in addition to traditional antihypertensive medications, often receive magnesium supplementation and are at increased risk of postspinal hypotension Postspinal hypotension increases the risk of fetomaternal morbidity.
Calcium is a physiological antagonist of magnesium in vascular smooth muscle. Therefore, the study hypothesized that calcium is better suited for preserving systemic vascular resistance and preventing postspinal hypotension during cesarean delivery.
The study aimed to evaluate the effect of prophylactic calcium administration on postspinal hypotension in preeclamptic women receiving magnesium supplementation. This prospective, randomized, placebo-controlled, double-blinded, two-arm parallel trial was conducted in preeclamptic women receiving magnesium sulfate supplementation undergoing cesarean delivery. The women were randomized to receive intravenous calcium or a placebo (normal saline) before spinal anesthesia. The study drug (calcium gluconate 500 mg or normal saline) was administered over 15 minutes and ended immediately before spinal anesthesia. The primary outcome measure was the incidence of postspinal hypotension, and secondary outcome measures were postpartum blood loss and maternal and neonatal outcomes.
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