PTerm Classifier promising tool for Accurately Predicting Preterm Birth: Study Finds
China: In a significant advancement for prenatal care, researchers have developed a blood-based classifier called PTerm that can accurately predict the risk of preterm birth using genome-wide patterns in cell-free DNA (cfDNA). This innovative tool, which leverages existing non-invasive prenatal testing (NIPT) data, offers a highly accurate and cost-effective method for early detection of at-risk pregnancies.
The findings were published online in PLOS Medicine on April 15, 2025.
Preterm birth (PTB)—delivery before 37 weeks of gestation—remains a global challenge, affecting around 11% of pregnancies and contributing significantly to neonatal complications and maternal health risks. PTerm harnesses cfDNA, which circulates in the maternal bloodstream and reflects genetic material from the placenta and other maternal tissues. Because these DNA fragments dynamically respond to biological and pathological changes during pregnancy, they serve as a valuable biomarker for anticipating complications such as PTB.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.