Serum leptin can be a predictable marker for gestational diabetes mellitus: IJOGR
Gestational Diabetes Mellitus (GDM) is one of the most prevalent conditions associated with pregnancy, and if untreated it can have a major negative impact on both the mother’s and the child’s health. It affects 3-8% of pregnancies and is defined by glucose intolerance identified during pregnancy due to obesity risk. The etiology of GDM remains poorly understood. The most widely accepted explanation states that human placental lactogen, prolactin, glucocorticoids, and progesterone all of which are released by the placenta during pregnancy cause GDM by lowering insulin sensitivity and boosting anti-insulin hormones. Adipocytes produce adipocytokines likes leptin that contribute to energy balance, metabolism of glucose and insulin. According to certain research, leptin may also play a major role in controlling the body’s overall glucose homeostasis. Leptin may therefore play a significant role in the onset and prognosis of GDM. There is a favorable relationship between plasma leptin concentrations and both direct and indirect markers of obesity. Leptin levels rise in expectant mothers who have altered maternal fat reserves and glucose metabolism. The concentration of leptin in mothers rises two to three times higher than in non-pregnant women, peaking at 28 weeks of gestation.
This study assessed the serum leptin concentrations for development of gestational diabetes mellitus. It is a case-control study, included 120 participants (60: Gestational Diabetes Mellitus Cases and 60: Healthy Controls). Authors assed BMI, FBS, HbA1c, Lipid Profile and serum leptin. Results: The serum leptin concentrations were significantly elevated in patients with gestational diabetes mellitus when compared to controls (P=0.001). There was a significant positive correlation between the serum leptin and BMI, FBS, HbA1c, Total Cholesterol and LDL (P=0.001).
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