Short and Long Interpregnancy Intervals Linked to Higher Risk of Spontaneous Abortion: JAMA
Researchers have found that both short and long interpregnancy intervals (IPI) following a healthy live birth are associated with an increased risk of subsequent spontaneous abortion (SA). This significant finding highlights the importance of optimal birth spacing to improve perinatal outcomes. The study was recently published in JAMA Network Open by Xuan H. and colleagues.
The interval between pregnancies is a potentially modifiable factor that has been linked to various adverse perinatal outcomes. However, the specific impact of IPI on the risk of spontaneous abortion has not been well understood. This study aimed to fill that gap by analyzing data from a large cohort of women who participated in the Chinese National Free Prepregnancy Checkups Project over a decade.
This prospective cohort study included 180,921 women aged 20 to 49 years who had a single healthy live birth and were planning another pregnancy. The study period spanned from January 1, 2010, to December 31, 2020, with statistical analysis conducted from June 20 to October 5, 2023. The primary exposure was the interpregnancy interval, defined as the time between the delivery date of the first live birth and the conception of the subsequent pregnancy. IPIs were categorized into five groups: less than 18 months, 18 to 23 months, 24 to 35 months, 36 to 59 months, and 60 months or longer. The main outcome measured was spontaneous abortion (SA).
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