Should breastfeeding continued during Coronavirus treatment?

New Rochelle -Currently there is no antiviral proven to be effective against COVID-19, the coronavirus, that originated in Wuhan, China, and spreading worldwide.

However, one investigational drug appears promising, remdesivir.   was developed to treat Ebola, but it shows very good activity against COVID-19 in vitro and in some animal models. It is now in phase III clinical trials, meaning that its toxicity was acceptably low in phase I and II trials. In China, it is being studied in a randomized controlled trial in patients with SARS-CoV-2. 

In addition, a patient with confirmed SARS-CoV-2 was treated in Seattle with intravenous (IV) remdesivir and appeared to respond well with no side effects.2 Nothing is known about the passage of remdesivir into breastmilk, but one newborn infant with Ebola was treated with IV remdesivir following treatment with the monoclonal antibody ZMapp and a buffy coat transfusion from an Ebola survivor. 

Little data is available about the ability of antiviral drugs used to treat COVID-19, coronavirus, to enter breastmilk, let alone the potential adverse effects on breastfeeding infants. A new perspective article reviewing what is known about the most commonly used drugs to treat coronavirus and influenza is published in Breastfeeding Medicine, the official journal of the Academy of Breastfeeding Medicine published by Mary Ann Liebert, Inc., publishers. Click here to read the protocol free on the Breastfeeding Medicine website.

Philip Anderson, PharmD, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, is the author of "Breastfeeding and Respiratory Antivirals: Coronavirus (COVID-19) and Influenza." The short answer to questions regarding drug therapy for COVID-19 is that currently there is no antiviral agent proven to be effective against this new infection. However, one investigational drug so far, remdesivir, appears promising to treat COVID-19, and it is in phase 3 clinical trials in patients. Dr. Anderson notes: "Nothing is known about the passage of remdesivir into breastmilk."

Arthur I. Eidelman, MD, Editor-in-Chief of Breastfeeding Medicine, states: "Given the reality that mothers infected with coronavirus have probably already colonized their nursing infant, continued breastfeeding has the potential of transmitting protective maternal antibodies to the infant via the breast milk. Thus, breastfeeding should be continued with the mother carefully practising handwashing and wearing a mask while nursing, to minimize additional viral exposure to the infant."

For more details click on the link: http://dx.doi.org/10.1089/bfm.2020.29149.poa