Sickle Cell Disease during pregnancy Significant Risk Factor for Maternal-Fetal Morbidity, finds study

Researchers have found that sickle cell disease (SCD) poses a significantly increased risk for maternal-fetal morbidities, especially in the last month of pregnancy. This is concluded by one of the largest studies into SCD pregnancies in India, undertaken at Kasturba Maternity Hospital, Gujarat. The study was conducted by Kapilkumar Dave and colleagues published in the International Journal of Obstetrics and Gynecology.
The study sought to quantify maternal-fetal risks associated with SCD and sickle cell traits and explore the epidemiology of maternal morbidity. The results are of utmost importance for critical insights into how SCD affects pregnancy outcomes and can provide actionable information on strategies to improve care in resource-limited settings.
This retrospective cohort study enrolled all pregnant women admitted to Kasturba Maternity Hospital from 2016 to 2021. In five years, there were 24,256 deliveries. The screening for SCD was done in these women, and pregnancy-related complications are documented meticulously. The analysis of risks was done with the help of Poisson and logistic regression models after accounting for confounding variables.
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