Study compares Pregnancy outcomes of fresh with cryopreserved-thawed embryo transfer
The use of cryopreserved donor oocytes in the United States has been steadily increasing. One question that remains unanswered about cryopreserved donor oocytes is whether there is a difference in pregnancy outcomes among patients who use a fresh embryo transfer (ET) compared with patients who cryopreserve the resulting embryo, followed later by a frozen ET. Given the widespread use of frozen donor oocytes, determining whether an association exists between either fresh or cryopreserved-thawed ET and the resulting pregnancy outcome is imperative. Therefore, this study by Lauren Barrison et al evaluated pregnancy outcomes among frozen donor oocyte cycles, comparing fresh ET with cryopreserved-thawed ET.
This retrospective cohort study examined donor oocyte thaw cycles using cryopreserved oocytes from Donor Egg Bank USA between 2016 and 2021. The study received institutional review board approval. Donor Egg Bank’s standardized protocols were followed for donor screening, donor stimulation, oocyte retrieval, oocyte vitrification, and oocyte shipping. Authors included donor cycles with oocyte lots that were received by 2 different recipients, with one undergoing fresh blastocyst transfer and one undergoing cryopreservedthawed blastocyst transfer. The primary outcome was an ongoing pregnancy, defined as a viable intrauterine pregnancy at the time of referral to an obstetrician at approximately 8 weeks of gestation. Secondary outcomes included additional pregnancy and embryonic development outcomes
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