Study Finds Elevated Serum Survivin Linked to Placental Disorders, Highlighting Its Role in Placenta Previa and PAS

The study revealed significant associations between elevated serum survivin levels and placental disorders, specifically placenta previa and PAS, suggesting a potential role for survivin in the pathogenesis of these complications. While the cross-sectional design provides valuable insights, the researchers emphasize the need for future longitudinal studies with repeated measurements of serum survivin levels at various gestational stages.

Such studies would help identify thresholds for high-risk pregnancies and assess survivin's utility in clinical practice. Including non-pregnant controls and examining survivin levels in early pregnancy could further clarify its role in normal and pathological placentation. These longitudinal studies could also explore whether changes in survivin levels precede clinical manifestations of placental disorders, offering opportunities for early intervention.

"Overall, the findings contribute to a deeper understanding of placental pathologies and set the stage for future research on biomarkers for placental disorders, potentially improving diagnosis and treatment strategies," the researchers concluded.

Reference:

Yilmaz, N., Bakirci, I. T., Sahin, B., Bolluk, G., Can, E., & Dedeakayogullari, H. (2025). Assessment of serum survivin in women with placenta previa and accreta spectrum: A cross-sectional study. Scientific Reports, 15(1), 1-7. https://doi.org/10.1038/s41598-025-89384-4