Terbinafine use safe during pregnancy: JAMA
A new study published in JAMA Dermatology has declared Terbinafine use safe during pregnancy. Terbinafine is assigned as category B to pregnancy by the FDA.;
Denmark: Terbinafine is a commonly used antifungal agent, but safety data of its use in pregnancy are limited. It has been assigned to pregnancy category B by the FDA.
A recent study publishes in the JAMA Dermatology shows that both oral and topical forms of the antifungal agent terbinafine seem safe to use during pregnancy. A nationwide, registry-based cohort study was conducted in Denmark from January 1, 1997, to December 31, 2016, which included 1, 650, 649 pregnancies.
Based on the study, oral terbinafine-exposed (n = 891 pregnancies) and topical terbinafine-exposed (n = 3174) pregnancies were identified; up to a total of 40, 650 unexposed pregnancies were included for the matched outcome analyses.
In the view of the risk of major malformations, the prevalence odds ratios were
1)1.01 for oral terbinafine-exposed vs unexposed pregnancies,
2)1.08 for topical terbinafine-exposed vs unexposed pregnancies, and
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