Trisomic conceptions associated with subsequent diagnoses of infertility, reveals research
Researchers in a recent study found that women who had trisomic pregnancies were at a higher risk of being diagnosed with infertility in the later years. A study was published by Satu W. and colleagues in the International Journal of Obstetrics and Gynecology. The authors carried out a nationwide cohort study in Finland to determine any linkage with gynecologic or reproductive disorders with regard to trisomic conceptions. The data sources were obtained from the Registry of Congenital Malformations and the Finnish Maternity Cohort.
In this large study, cases comprised all women with a pregnancy trisomy between 1987 and 2018, while the respective trisomies were T13 (n=351), T18 (n=1065), and T21 (n=4369), each matched with population controls based on age, residence, and timing of pregnancy.These cases were cross-linked to ICD-10 diagnoses from the National Care Registry for Health Care, covering the period 1996–2019. The research was restricted both to inflammatory disorders, ICD-10: N70–N77, and non-inflammatory disorders of the genital tract, ICD-10: N80–N98. Crude odds ratios with 95% confidence intervals were calculated to estimate the associations of such diagnoses with trisomic conception.
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