Ultrasound screening not useful in lowering mortality rates in ovarian cancer: Lancet
According to a study report published in The Lancet, long-term follow-up (median 16·3 years after randomisation), neither multimodal screening(MMS) or transvaginal ultrasound screening (USS), significantly reduced deaths from ovarian and tubal cancer.
Ovarian cancer continues to have a poor prognosis with the majority of women diagnosed with advanced disease. Therefore, researchers undertook the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) to determine if population screening can reduce deaths due to the disease.
The aim of the largest ovarian cancer screening trial to date was to report on ovarian cancer mortality after long-term follow-up in UKCTOCS.In this randomised controlled trial, postmenopausal women aged 50–74 years were recruited from 13 centres in National Health Service trusts in England, Wales, and Northern Ireland. Exclusion criteria were bilateral oophorectomy, previous ovarian or active non-ovarian malignancy, or increased familial ovarian cancer risk. The trial management system confirmed eligibility and randomly allocated participants in blocks of 32 using computer generated random numbers to annual multimodal screening (MMS), annual transvaginal ultrasound screening (USS), or no screening, in a 1:1:2 ratio. Follow-up was through national registries.
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