Use oral corticosteroids in Pregnancy not tied to Increased Gestational Diabetes Risk: JAMA
In a nationwide study, researchers indicated that oral corticosteroids (OCSs) were not associated with an increased overall risk, except for a modest increase when used between 4 and 6 weeks’ gestation. The study was published in the JAMA Internal Medicine journal by Eun-Young C. and colleagues.
This cohort study used a national, population-based sample that initially included 3,848,270 pregnancies, of which 1,325,940 met all eligibility criteria. Exposure to OCSs was evaluated in 3-week windows using a sequential landmark analysis to reduce time-related biases. Of the total number, 79,710 pregnancies (6.0%) were exposed to OCSs during early to mid-pregnancy. Gestational diabetes was ascertained starting at 20 weeks + 1 day through delivery using a well-validated claims-based algorithm. The authors performed propensity score–based overlap weighting to reduce confounding, including maternal comorbidities, concomitant medications, and patterns of health care use.
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