Vitamin D3 Improves Glucose Levels but Shows Limited Impact on Insulin Sensitivity among women with PCOS: Study
Researchers have found in a new study that Among women with PCOS, Vitamin D3 supplementation significantly improves glucose metabolism, as seen by reduced fasting and 2-hour blood glucose levels. However, it shows minimal overall effect on insulin sensitivity markers like HOMA-IR. Despite an 84% increase in blood 25-hydroxyvitamin D levels, the impact on insulin resistance was complex and subtle.
While some correlation was noted between changes in HOMA-IR and Vitamin D levels, no consistent improvement in insulin sensitivity was observed across subgroups. Higher doses and longer studies are needed to fully understand vitamin D’s role in glucose regulation.
Among premenopausal women, polycystic ovarian syndrome (PCOS) is one of the most ubiquitous endocrine and metabolic conditions. Abdominal adiposity, insulin resistance, obesity, metabolic diseases, and cardiovascular hazards are often associated with PCOS. This investigation aims to decipher the influence of oral Vitamin D3 supplementation (2000 IU/day for three months) on glucose metabolism in PCOS women. 123 subjects (females 16 to 40 years of age) were arbitrarily allocated to three cohorts (n = 41 in each cohort) Each participant received two tablets daily and a sachet every month for three months (Group I: Vitamin D3 Tablets + placebo sachets; Group II: Placebo Tablets + Vitamin D3 sachets; Group III: Tablets + Placebo sachets). RESULTS: Among 123 PCOS subjects, 93.4% exhibited hypovitaminosis D.
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