Women with early menopause likely to have higher risk of heart failure, reveals study

Results : The mean age was 65.1 years. Over a median follow-up period of 17.8 years, 45 HF events occurred. After adjusting for waist circumference, other cardiovascular disease risk factors and myocardial infarction, the hazard ratios (95% confidence intervals) of incident HF attributable to early menopause were 4.50 (1.41-14.3), 4.64 (1.46-14.7), and 5.16 (1.59-16.7) in models that additionally included adiponectin, leptin, and resistin, respectively. In adjusted analyses, adiponectin was independently associated with incident HF 2.20 (1.35-3.57), while leptin and resistin were not.

The interaction terms of early menopause with adiponectin, leptin, and resistin for incident HF were not significant (Pint = 0.08-0.82). Early menopause was significantly associated with incident HF. This association did not differ by serum adipokine levels. Only adiponectin was independently associated with incident HF in postmenopausal women when waist circumference, body mass index, and waist-hip ratio were used as the adiposity metric.

Reference:

Ebong, Imo A. MD, MS1,2; Wilson, Machelle PhD1,2; Michos, Erin D. MD, MHS3; Appiah, Duke PhD4; Schreiner, Pamela J. PhD5; Racette, Susan B. PhD6; Allison, Matthew MD7; Watson, Karol MD, PhD8; Bertoni, Alain MD, MPH9. Menopausal age, adipokines, and heart failure incidence in postmenopausal women of Multi-Ethnic Study of Atherosclerosis. Menopause ():10.1097/GME.0000000000002456, December 3, 2024. | DOI: 10.1097/GME.0000000000002456