Aspirin may Reduce Pancreatic Cancer Risk in Type 2 Diabetes Patients, finds study
Researchers have indicated that aspirin may be an effective preventive strategy against pancreatic cancer (PC) in patients suffering from type 2 diabetes mellitus (T2DM). A recent study was conducted by Jing T. and colleagues in Hong Kong which was published in the journal Gut.
This retrospective study used data from 343,966 newly diagnosed adult T2DM patients in Hong Kong between 2001 and 2015. Excluded were patients with prior PC, pancreatic cysts, IgG4 disease, or pancreatectomy, as well as those diagnosed with PC within one year of T2DM diagnosis to account for reverse causality. Aspirin use was treated as a time-varying variable to avoid immortal-time bias, defined as ≥180 days of use per year. The study used a multivariable Cox regression model and propensity-score matching to explore the effects of aspirin on risk of PC as well as PC-specific mortality.
Key findings
Pancreatic Cancer Incidence
• Of patients included in this cohort, 1,224 (0.36%) were diagnosed with PC during the follow-up period.
Risk of PC was significantly lower for aspirin use:
• Time-varying effect: aHR was 0.58 (95% CI 0.49 to 0.69).
• Propensity score matching analysis: aHR 0.61 (95% CI 0.48 to 0.77).
Dose-Response Relation
• A clear inverse relationship was noted, and higher doses and longer durations of aspirin use were associated with greater risk reduction (p<0.001).
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