Cachexia index as a Biomarker for Cancer Cachexia and Quality of Life in Gastric Cancer: Study
Researchers have found in a new study that cachexia index (CXI) may be a valuable indicator for assessing cancer cachexia and health-related quality of life in gastric cancer patients. The study was published in BMC Cancer journal by Yan H. and colleagues.
Cachexia, a multifaceted metabolic syndrome involving intense muscle wasting and weight loss, is well recognized to be connected with unfavorable clinical outcomes in GC patients. In the present study, CXI was calculated according to the following formula: skeletal muscle index (SMI) × serum albumin / neutrophil–lymphocyte ratio (NLR). The present study was conducted to determine if CXI could efficiently detect cachexia and foretell HRQoL impairments.
The analysis involved 431 patients with GC, made up of 309 men (71.7%) and 122 women (28.3%), with an age at median of 68 years. Diagnosis of cachexia was made according to both AWGC criteria and Fearon's criteria. Univariate logistic regression and multivariate logistic regression analyses were employed to determine independent risk factors for cachexia and for poor HRQoL. ROC curve analysis was conducted to establish diagnostic performance of CXI in diagnosing cachexia, as well as calculate the area under the curve (AUC).
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