Can breast cancer be detected through spit test?

Scientists have developed a saliva test that screens for breast cancer, which is showing promising results in experimental testing, according to a study published Tuesday.

The new hand-held device detects breast cancer biomarkers from a tiny sample of spit, say researchers from the University of Florida and National Yang Ming Chiao Tung University in Taiwan, who published their findings in the Journal of Vacuum Science & Technology B.

“Imagine medical staff conducting breast cancer screening in communities or hospitals,” said Hsiao-Hsuan Wan, a UF doctoral student in the Department of Chemical Engineering and the study’s lead author. “Our device is an excellent choice because it is portable-about the size of your hand-and reusable. The testing time is under five seconds per sample, which makes it highly efficient.”

The new tool works by placing a saliva sample on a test strip, which is treated with specific antibodies that respond to cancer biomarkers. Electrical impulses are sent to contact points on the biosensor device. Signals are measured and translated into digital information about how much biomarker is present. The results are quick and easy to interpret, Wan said.

During testing, the device distinguished between healthy breast tissue, early breast cancer, and advanced breast cancer in a small group of 21 women. Their biosensor design uses common components like glucose testing strips and the open-source hardware-software platform Arduino.

Reference:

Hsiao-Hsuan Wan, Haochen Zhu, Jian-Sian Li, Fan Ren, Cheng-Tse Tsai; Yu-Te Liao; Dan Neal, Josephine F. Esquivel-Upshaw, Stephen J. Pearton, High sensitivity saliva-based biosensor in detection of breast cancer biomarkers: HER2 and CA15-3, Journal of Vacuum Science & Technology B, https://doi.org/10.1116/6.0003370.