Chemotherapy decreases Overall Mortality of metastatic urachal carcinoma: Study

Overall, the very aggressive nature of metastatic urachal carcinoma (m-UraC), when distant metastases are present, and observed that m-UraC patients exposed to chemotherapy exhibited lower overall mortality (OM) and cancer-specific mortality, according to a new study conducted by Rocco Simone Flammia and team (CSM). The findings of this study were published in the Journal of Urologic Oncology.

Urachal carcinoma is a rare non-urothelial cancer that commonly affects the bladder's midline or dome as a result of direct extension from the urachal ligament, which is where the tumour originates. Urachal cancer usually manifests at an advanced stage because tumour development is silent. For localized disease, surgery has been found to be successful, but there is no proven treatment for metastasis. The researchers used the most recent Surveillance, Epidemiology, and End Results (SEER) database to test the hypothesis that chemotherapy may improve survival in m-UraC patients.

m-UraC patients aged 18 years were identified in the SEER database (2004-2016). Overall mortality (OM) and cancer-specific mortality (CRR) were addressed using propensity score matching (PSM: cystectomy status, age, and gender), Kaplan-Meier plots, cumulative incidence plots, Cox regression models, and competing risks regression (CRR) models (CSM).

The findings of this study are as follows:

1. There were 274 m-UraC patients in total, with a median age of 70 years. The majority (66 percent) were Caucasian men (72% ).