Early Metabolic Syndrome Linked to High Pancreatic Cancer Risk: Lancet
A recent retrospective observational study found compelling evidence of increased incidence of pancreatic cancer associated with the early stages of metabolic syndrome (MetS). The findings of the study were published in Lancet eClinicalMedicine.
This study recruited a staggering 4.6 million Japanese participants in 2005 with rigorous follow up of over a decade. The clinical data, prescribed drug regimens, and the presence of MetS using modified criteria from the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATPIII) were meticulously analyzed. Out of the 2,707,296 subjects without pancreatic cancer at enrollment, 87,857 eventually developed pancreatic cancer during the 40.7-month average follow-up.
The incidence of pancreatic cancer was markedly higher in the MetS group (4.9%) compared to the non-MetS group (3.0%), with a statistically significant hazard ratio (HR) of 1.37 (95% confidence interval [CI], 1.34–1.39) after adjusting for age, smoking, and sex. Also, with increase in the number of MetS constituent factors from one to five, there was a corresponding rise in the incidence of pancreatic cancer which signify a dose-response relationship.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.