Extended surveillance among low-risk pancreatic cysts leads to fewer progression to advanced neoplasia

Results:

Forty-one eligible studies underwent systematic review, and eighteen studies were meta-analyzed. The pooled incidence of WF/HRS among low-risk BD-IPMNs during initial and extended surveillance was 2.2% patient-years, respectively. In contrast, the incidence of advanced neoplasia was 0.6% and 1.0% patient-years, respectively. The pooled incidence of disease-specific mortality during initial and extended surveillance were 0.3% and 0.6% patient-years, respectively. Among BD-IPMNs with initial size stability, extended surveillance had WF/HRS and advanced neoplasia incidence of 1.9% and 0.2% patient-years.

A key finding of this study is a lower incidence of advanced neoplasia during extended surveillance among low-risk, stable-sized BD-IPMNs. However, the survival benefit of surveillance among this population warrants further exploration through high-quality studies before recommending surveillance cessation with certainty.

Reference:

The benefit of extended surveillance of low-risk pancreatic cysts after five-year stability: a systematic review and meta-analysis by Ankit Chhoda, et al. published in the Clinical Gastroenterology and Hepatology

DOI: https://doi.org/10.1016/j.cgh.2022.04.025