Hormonal Contraceptives Increase Breast Cancer Risk in Women of Reproductive Age
A recent comprehensive study published in the Cancers Journal indicated a higher risk of breast cancer (BC) among women who have used hormonal contraceptives (HC) during their lifetime. This study shows the intricate relationship between hormonal contraceptives and breast cancer with a special focus on women of reproductive age.
The data from observational studies around the years 2015 to 2022 were pooled. This examined a total of 724 studies and narrowed down to 22 for meta-analysis by including 19 case-control studies and 3 cohort studies. The findings of the study revealed a significantly elevated risk of developing breast cancer in ever-users of hormonal contraceptives (pooled OR = 1.33; 95% CI = 1.19 to 1.49). The risk was found to be intensified in case-control studies (pooled OR = 1.44, 95% CI = 1.21 to 1.70) and in studies strictly defining menopausal status (pooled OR = 1.48; 95% CI, 1.10 to 2.00).
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