Hormone therapy linked to reduced risk of colorectal cancer: Study
Menopausal hormone therapy is associated with an overall reduced odds for colon and rectal adenocarcinoma, especially among women aged 40 to 60 years.
Sweden: The use of menopausal hormone therapy (MHT) may lessen the risk of colorectal cancer (CRC) in women, finds a recent study in the journal Alimentary Pharmacology & Therapeutics.
Menopausal hormone therapy has been associated with various malignancies. Qing Liu, Karolinska Institutet, Stockholm, Sweden, and colleagues aimed to investigate the association of various MHT regimens with the risk of colorectal cancer.
The study included all the MHT ever-users (n = 290 186) through the Swedish Prescribed Drug Registry, with a 1:3 group-level matching to non-users. Ever-users were defined as women who received ≥1 dispensed prescription of systemic MHT during 2005-2012 in Sweden. All CRC cases following the drug initiation were extracted from the Swedish Cancer Registry.
The association was assessed by multivariable conditional logistic and Cox regression models, presented as odds ratios (ORs) or hazard ratios (HRs) with 95% confidence intervals (CIs) considering different regimens, duration, and age at treatment initiation.
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