Innovative oncolytic virus and immunotherapy combinations pave way for advanced cancer treatment: Study

By combining OVs with cellular immunotherapy, immune checkpoint inhibitors, cancer vaccines, cytokines, and bi- or tri-specific T cell engagers, researchers have developed innovative strategies that overcome the limitations of OV monotherapy. These synergistic treatments amplify the body’s natural defenses, creating a powerful dual attack against cancer cells while minimizing adverse effects.

One of the key breakthroughs in this field has been the ability to genetically modify OVs to enhance their tumor-targeting efficiency. Modified viruses can express immune-stimulating molecules, improving their ability to recruit and activate immune cells within the tumor microenvironment. This has led to remarkable improvements in tumor eradication, particularly in difficult-to-treat cancers.

The potential of OV-based combination therapies extends across multiple cancer types, including solid tumors, where conventional treatments often fall short. With ongoing clinical trials and continued research into the underlying anti-tumor mechanisms, these therapies are expected to become a cornerstone of next-generation cancer treatment.

As the field of precision medicine continues to evolve, oncolytic virus-based combination immunotherapy is emerging as a promising and effective strategy for patients worldwide. With its ability to enhance immune activation, improve treatment efficacy, and reduce toxicity, this novel approach represents a significant step forward in the fight against cancer.

Reference:

Xiaoli Zhou, Shunfeng Hu, Xin Wang, Recent advances in oncolytic virus combined immunotherapy in tumor treatment, Genes & Diseases, https://doi.org/10.1016/j.gendis.2025.101599.