Liquid biopsy may help diagnose cancer faster than tissue biopsy: Study
Denver - A pilot study comparing the effects of a liquid biopsy with tissue-based test showed that liquid biopsy turn-around time for results was approximately 10 days faster than the tissue biopsy, according to research presented today at the IASLC 2020 Lung Cancer Hot Topic: Liquid Biopsy Virtual Conference.
Oncologists and pathologists prefer tissue-based analysis for patients with lung cancer, but liquid biopsy may provide a salvage approach in case of tissue exhaustion and may even be faster than tissue-based analysis according to Nir Peled, MD, a medical oncologist and Head of the Cancer Institute, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel.
Dr. Or Sehayek, Dr. Peled and their colleagues developed a pilot study and evaluated 25 patients with treatment-naive advanced metastatic non-small cell lung cancer (NSCLC). Dr. Peled sought to compare time to report and time to treatment for next-generation sequencing (NGS)-based liquid biopsy vs. tissue-based analysis.
Tissue and blood biopsies were ordered for all patients. Tissue-based analysis was based on local standard of care, which was immunohistochemistry for ALK, ROS1, and PCR or amplicon-based NGS for EGFR mutation statuses. Each patient also was given a liquid NGS platform blood biopsy.
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