Metformin and Vitamin D Improve Clinical Outcomes of Cholangiocarcinoma: Study
Cholangiocarcinoma (CCA) is the most common biliary malignancy and the second most common hepatic malignancy after hepatocellular carcinoma (HCC). A recent study suggests that Vitamin D intake improves disease-free survival (DFS) in patients undergoing surgery and Metformin intake improves the clinical outcome in advanced disease. The research has been published in the journal Oncology on February 24, 2021.
In the last few years, there has been increasing interest in non-cancer medications and their potential anti-cancer activity. Data are not available in cholangiocarcinoma (CCA) patients. Several in vitro and in vivo studies have indicated that metformin inhibits the growth of gastric, esophageal, and hepatocellular carcinoma cells. However, the effect of metformin and Vitamin D, especially in CCA remains unknown. Therefore, researchers of Italy conducted a study to fill this gap by investigating the potential impact in terms of clinical outcome of the common non-cancer medications.
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