Pre and Postoperative eGFR independent risk factor for CKD after Radical Nephrectomy
A new study found that preoperative estimated glomerular filtration rate (eGFR), age, and immediate postoperative eGFR are independent risk factors for postoperative chronic kidney disease. The study results were published in the journal BMC Cancer.
The most common treatment for localized renal cell carcinoma is radical nephrectomy (RN). Postoperative chronic kidney disease could result from the decreased number of nephrons due to RN. Hence researchers conducted a study to understand the incidence and risk factors for CKD in patients who have received RN.
Between January 2010 to December 2018, at Zhejiang Provincial People's Hospital, a total of 1233 patients underwent radical nephrectomy. Patients with abnormal renal function before surgery or who were lost to follow-up were excluded from the study. Five hundred patients were enrolled and their eGFR was calculated using the abbreviated MDRD equation. CKD was defined as eGFR less than 60 ml/min/1.73m2. Kaplan-Meier method was used to estimate the incidence of postoperative CKD. logistic multivariate regression analysis was used to determine the independent risk factors for CKD.
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