Radiation therapy in breast cancer linked to increased risk of melanoma and hemangiosarcoma: JAMA
Previous studies have suggested a potential link between radiation therapy for breast cancer and an increased risk of subsequent nonkeratinocyte skin cancers. However, the evidence supporting this association has been limited. A recent population-based cohort study aimed to investigate whether radiation therapy for breast cancer is associated with an elevated risk of developing nonkeratinocyte skin cancers, particularly localized to the skin of the breast or trunk.
This study was published in the journal JAMA Network Open by Shawheen J. and colleagues. Radiation therapy is a common treatment modality for breast cancer, but its potential long-term effects on skin health have been a subject of concern.
This study utilized longitudinal data from the Surveillance, Epidemiology, and End Results (SEER) Program, covering the period from January 1, 2000, to December 31, 2019. Patients with newly diagnosed breast cancer were identified, and subsequent development of nonkeratinocyte skin cancers was evaluated. Standardized incidence ratios (SIRs) were calculated to assess the risk of nonkeratinocyte skin cancer development based on treatment type (radiation therapy, chemotherapy, or surgery), skin cancer site, and subtype.
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